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KMID : 1059520220660010009
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Journal of the Korean Chemical Society
2022 Volume.66 No. 1 p.9 ~ p.14
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Intramolecular Oxa-Mannich Reaction of 1,3-Dihydro-2-benzofuran-1-ol for Efficient Synthesis of 1-Aminophthalan Derivatives
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Kim Hee-Bum
Kim Sung-Gon
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Abstract
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An efficient method for the synthesis of 1-aminophthalans has been developed. The intramolecular oxa-Mannich reaction of 1,3-dihydro-2-benzofuran-1-ols with p-toluenesulfonylamine in the presence of Cs2CO3 as a base, without using any catalyst, provided the desired 1-aminophthalans in moderate to good yields.
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KEYWORD
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1,3-Dihydroisobenzofuran, Phthalan, p-Toluenesulfonylamine, Mannich reaction
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